Can Ancestry Dna Be Uploaded to Prometheus
Hither at Family History Daily we've covered DNA testing for genealogy research pretty extensively, simply we've always focused on beginnings reports, non wellness reports. This is because nosotros've ever felt that the genetic "health" information provided today, which is however very much in its infancy, could exist taken out of context and perchance cause distress and confusion to some users. In fact, some data offered by certain websites seems designed to mislead.
All the same, these reports are becoming more than common and many more people are taking reward of them. For this reason we have decided to embrace one of the more respected options so that you have a trusted source to plow to if you decide to explore your ain genetic health information.
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If y'all are interested in this blazon of reporting we encourage you be very wary nearly who yous are giving your DNA data to and how it may be used. Many places now offer free genetic reports, merely their history and intent is questionable. The site covered in this article has been around for quite a long time and has a clean record for data use, as well as very strict privacy and data storage limits.
Promethease is "a literature retrieval system that builds a personal Deoxyribonucleic acid report based on connecting a file of Deoxyribonucleic acid genotypes to the scientific findings cited in SNPedia." In fact, Promethease is a computer program congenital by SNPedia for scientific enquiry. The information folio most what they are and how they can be used can be establish hither.
According to their website, they only store your raw DNA data for 24 hours and your study for 45 days, to ensure proper use and privacy. The cost is not gratis, merely it is a minimal ($ten). For these reasons we take decided to cover them in this article. Notwithstanding, nosotros strongly encourage you lot to read their Privacy Policy and Terms and Weather before making your own determination equally to whether or not to take part.
In addition to privacy concerns, some people might exist bothered by health reports as they have the potential to reveal upsetting data almost your potential wellness. Please call back that your genes are only i function of the picture when information technology comes to your actual health and that the science behind these reports is developing all of the time. The author of this article, Matthew Gaskill, has taken the time to outline some warnings. Please take them seriously.
Family unit History Daily is Not an affiliate of Promethease and we volition Non receive revenue if you decide to upload your results to their site. We are, yet, an affiliate partner of 23andMe and they are linked to in this article considering they also provide health reports. AncestryDNA, MyHeritage Deoxyribonucleic acid and FTDNA are also linked to when they are discussed. If you choose to purchase a test with whatever of these companies after clicking on a link on our site we may earn a fee to support our piece of work.
How to Use Promethease to Get a Low Cost Genetic Health Report
by Matthew Gaskill
This is a simple introduction to the use of Promethease , a website which allows y'all to upload your raw DNA data (which tin be obtained from the DNA testing company yous sent your sample to – such as Ancestry, FTDNA, MyHeritage DNA or 23andMe), to receive a detailed report of biological traits and predispositions y'all carry inside yous.
Your Promethease report volition tell you (to the caste it is possible with the express raw data provided by testing companies) whether or not yous carry traits that MIGHT lead to certain medical conditions. Non all diseases or disorders are covered by a Promethease report, just at that place are a surprisingly large number of them.
Here are some screenshots from a sample written report. You can view the entire sample hither.
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Get 2 total weeks of complimentary access to more than than 12 billion genealogy records right now. Y'all'll also gain admission to the MyHeritage discoveries tool that locates information nearly your ancestors automatically when you upload or create a tree. What will you discover nigh your family'southward past?
A Few Words of Warning Before Using Promethease
First, while the results of the Promethease report are based on serious clinical studies and research, future findings may prove these results premature or wrong and then practise non take them as accented truth.
Second, many sections of your health report are explained in multipliers based on averages. For instance "7x risk of male person baldness." Does this mean that I am or WILL be bald? NO. It means that compared to the population studied (in this case, men in the United states) I accept a higher chance of becoming baldheaded. I am 55 and take a full head of pilus, as does/did literally everyone in my family, alive and dead. Though baldness is hardly serious, you can see that this example can employ to more serious weather condition as well.
What follows is a very important signal. Do non ignore this advice: If y'all are curious about your Dna makeup and what traits/tendencies it may carry, you may indeed want to upload your data to Promethease and received their medical report. Notwithstanding, I would highly recommend a few days of serious reflection before yous do this.
If you are a person who is bailiwick to whatever type of hypochondria or excessive worry, I would call up twice before running my information through Promethease. If y'all are non a worrier, you should yet requite careful consideration to whether or non you wish to find out what possible medical traits you comport.
The Promethease report is not to be taken lightly.
It is also highly recommended that y'all discuss the results of your Prometheus written report with your medico. If your physician is not familiar with this type of Deoxyribonucleic acid scientific discipline or report, ask he or she if they know some other medical professional who is. When using Promethease, prior knowledge and research is key. Your study should be read with a level head, with prior cognition of your own (and family's) medical history forefront in your mind.
As you read your written report, call back this: in many cases, some of your "bad" and "good" results will probable be offset by their opposites. For instance, in my case, Promethease gives me a better than average chance of developing heart bug based on certain DNA findings. Conversely, other DNA findings show that I have a amend than boilerplate adventure of reacting positively to "adept cholesterol" in a way that is a positive for my heart health. Equally with your Deoxyribonucleic acid genealogical findings, your Promethease results might get out you with more questions than you had when you began.
Why doesn't every DNA company offer medical reports?
In the last x years or so, the study of Dna genealogy has exploded. Virtually people submit their Dna to companies for the reason of finding out more about their particular family and or ethnic heritage. In some cases, people submit their Deoxyribonucleic acid in order to find birth parents or other long-lost relatives.
Initially, when 23andMe first advertised their Dna analysis they included a small number of examples of inherited DNA traits and /or relatively rare medical conditions for the consumer to analyze. Even so, in a number of instances, people jumped to the conclusion that considering they had the remote genetic possibility of developing a certain disorder or illness, they were at present certain to become it or had indeed already gotten it.
For this reason and others, the United States Food and Drug Administration (FDA) prohibited 23andMe and other United states of america-based genetic assay companies from releasing to the public any medical data based on the Deoxyribonucleic acid that had been supplied to them.
Over the course of a number of years 23andMe lobbied the FDA, improved their methods and enquiry, and in tardily 2016 was once again allowed to release a limited corporeality of information regarding medical conditions based on DNA testing.
However, fifty-fifty today in the bound of 2018, the information released by 23andMe regarding genetic predispositions carried by their clients is still relatively limited. The medical conditions and traits listed by them are for the almost part very rare and comprehend only (at the time of this writing) forty-ii conditions/syndromes. That is not to underestimate their importance to those who might carry the traits of those disorders, just still, we are talking about a very small percentage of the population at big.
In their advertising, 23andMe emphasizes the genetic ancestry and ethnic aspect of their services and the medical detection aspect of their service remains in the background. Other information regarding Deoxyribonucleic acid traits has to practice with taste, hearing, etc. For instance, it has been found that people with certain Deoxyribonucleic acid traits find the taste of cilantro pleasant, while others do not – not exactly earth-shattering information!
All the same, the FDA does not have jurisdiction outside of the boundaries of the United States. So, for a number of years, users of DNA analysis companies have had the ability to upload their raw DNA information to websites/organizations based outside of the United States. The nigh prominent of these is Promethease.
And so, how does Promethease piece of work?
Promethease is a byproduct of SNPedia, a wiki projection designed to tape all of the relevant inquiry information becoming available regarding human genetics.
SNP stands for single nucleotide polymorphism. What are SNP's – or "snips"? Very simply speaking, nucleotides are the building blocks of both DNA and RNA. Polymorphisms are the variations within these single nucleotides. The construction of these polymorphisms determine sure traits and their likelihood of occurring.
For example, rs10805007, is present in those of European descent with red hair. It besides marks an increased sensitivity to anesthetics, and perchance an increase in the likelihood of melanoma amid Europeans. The "Rs" in these codes stand for "reference SNP cluster ID." Within your Promethease results, you will exist able to click on the SNP's listed and read the data in greater length on SNPedia (which besides lists the scientific references/papers used to gather this data).
How To Upload Your Dna to Promethease
Uploading your raw DNA to Promethease is very fast once you've downloaded your raw data from your DNA testing company of choice. For help with that you may want to read my article nearly using GEDmatch, which gives instructions for finding this raw data.
Commencement, upload just the text file you downloaded from your Deoxyribonucleic acid testing company (not the entire .zip file). You can do this by choosing the greenish "upload raw information" selection shown beneath.
Once your data is uploaded, you must pay 10 dollars to receive your report. Once payment is processed (via Paypal or credit carte du jour), you can open your report in your browser. Be sure to your download your report and then that you tin access information technology after the forty-5 solar day menses that Promethease stores it on their server.
When you receive your Promethease results, you will have the opportunity to run them through various filters in order to weed through the tremendous corporeality of information that you lot are given.
The simplest of these filters are "good", "bad" and "no value." Depending on whether you're an optimist or pessimist, y'all may want to wait at good get-go or bad first. On the "bad" side, your Promethease study will tell you whether or not certain parts of your Dna precondition you to have cancer of various types, Alzheimer'south illness, stroke, coronary disease, and various mental illnesses. Remember to accept this with a grain of common salt and combine this with prior noesis. In my instance, I accept many indications that I will get Alzheimer's – I also accept many indications that I won't. Additionally, no one in my family has ever developed the affliction.
For the purpose of this commodity, I volition describe the quickest and near general way to get an overall picture of your Promethease written report. Once you are familiar with the written report, how the filters work, and what they mean – and accept become familiar with many unique terms you volition discover in your research — you can movement on to the more esoteric and/or hard filters, graphs and subjects.
Understanding Your Promethease Report
Go to the top right of your study and click on "categories." A separate window will appear that lists the topics within your report, a list of medicines, full general medical conditions, and ClinVar weather condition (run into definitions at the end of this article).
The first thing I would practise is Not to start looking up things like "cancer," or "heart affliction." I would look at the category chosen "medicine" and await and meet if whatever of the medicines I took were on the list, and/or if you knew there were other medicines used for medical atmospheric condition that you accept. In my example, I found that the anti-depressant I was taking before I read my Promethease study was not as effective equally others I could be taking instead. In consultation with my medico, I switched, and the result was significant. The medicine listed past Promethease was indeed better at treating my depression.
The second affair I would practise? Become through your report and scan it – don't allow yourself get too bogged down in the details, and don't get all tangled up in exterior studies (for now). Make certain you've not simply looked at your "bad" report only your "adept" i, as well. If y'all practice this ii or three times, you volition find that you've adult an overall mental picture of your DNA medical traits and some of the conditions that y'all may or may not accept a predisposition for.
In my case, one of the things I noticed was that "age-related macular degeneration" kept coming upward – with not only frequency but seriousness. This status can pb to blindness. I at present get my optics checked regularly – not just when I remember to every few years.
Some of your discoveries on Promethease might aid to explain why you behave in the way you lot do. This is the whole "nature/nurture" thing. I am not one who believes that DNA "forces" yous to practice anything, but it does predispose you to certain things.
Noesis is power. If you are aware of certain behaviors in yourself, you can do things to alleviate them or their frequency. In my instance, I am blessed (I use that term sarcastically) with the and so-chosen "Warrior Gene" – some people think it's a great thing to have. It is not. Believe me.
When I took the Promethease report as a whole it provided a meliorate picture show of my health and Deoxyribonucleic acid traits than if I focused on specific things. Every bit always, use the information independent in this written report in conjunction with prior knowledge of your own/family medical history. For instance, I knew from family history that eye conditions are a serious matter for me to pay attention to. Promethease reinforced this – strongly. The aforementioned with certain types of cancer that I know a parent and/or grandparent had.
In many cases, information technology'southward good for you to take some of what Promethease tells you lot with a grain (or two) or salt. For instance, my report states that I carry traits that signal the development of a sure cancer, all the same, the study cited for this shows that the clinical study group was Chinese men. Do I share DNA traits with Chinese men? I certainly practise – simply I differ enough to take this study at face value, and I don't panic, especially when this is the only study cited in the Promethease report.
Brand sure that you read your "good" traits as well. You will see that in many cases, Promethease cites studies that show certain people with certain traits react well to various things – like do, certain diets, etc. This is information that can mediate some of your feeling of unease when looking at your "bad" traits.
Once you are familiar with the navigation of the Promethease page and take familiarized yourself with some of the more difficult terms, do some experimenting. Modify filters, look around and use the data you glean to visit other sites. If you're like me, y'all will be amazed at the knowledge you have gained about yourself.
My Takeaway from Promethease
Did Promethease change my life? Yeah and no.
Did it make me more than aware of my medical conditions and any predispositions I might accept lying within my Deoxyribonucleic acid? No, not really – I already had a general thought of this from a good knowledge of family unit history. However, it did help me focus on areas that I need to keep in mind as I get older, like a trend towards sure types of cancer (bladder, testicular, prostate) that I already knew I was at adventure for.
All things considered, I highly recommend Promethease. But acquit in mind: nothing in your Promethease written report (except perhaps your blood blazon) should be taken equally complete truth. It should ever be paired with other reliable knowledge and your medico's advice/input.
Delight see the International Social club of Genetic Genealogy'southward Wiki for a glossary of terms to help you decipher your reports.
Matthew Gaskill holds an MA in European History and writes on a multifariousness of topics from the Medieval World to WWII to genealogy and more. A former educator, he values curiosity and diligent research. He is currently working on a novel based on his ain family unit history.
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Source: https://familyhistorydaily.com/genealogy-help-and-how-to/promethease-genetic-health-report/
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